Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3064 | 3064-30327 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54IMV, V82A, L90M | K43T, F53L | L10I, G16E, L19LI, K20KR, M36MI, D60E, L63P, I64IV, A71IT, I93L |
| >3064-30327| codons 4-99 TLWQRPIVTIKIEGQIREALLDTGADDTILEEINLPGRWTPKIVGGIGGLVKVRQYEQIP VEICGHKTIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, L210LW, T215FY | K219E | K103KN | T39TA, E40FV, K43N, V60I, T69N, V118VI, D121Y, K122E, I142IV, D177E, I178IM, V179I, G196E, T200TA, H208HY, R211RK, L228H, Q242QH |
| >3064-30327| codons 38-247 CAVLENEGKISKIGPENPYNTPIFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLYEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEMIIYQYVDDLYVGSDLEIEQHRAKIEELRQYLWKWGFYTP DEKHQKEPPFHWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |