Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3036 | 3036-30606 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | L10F, G73T | I15V, K20M, L63P, I64V, C67D, H69R, A71V, I93L |
| >3036-30606| codons 4-99 TLWQRPFVTIKVGGQLMEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYDQIP VEIDGRKVITTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75VIM, M184V, L210W, T215Y | K103N | V108I | T39TA, S48T, V60I, K101Q, V118VI, D121H, K122E, I135T, D177E, V189I, T200IL, I202V, R211K, E224D, D237E, Q242QP |
| >3036-30606| codons 38-247 CAELEKEGKITKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLQKNKSVTILDVGDAYFSIPLHEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYVDDLYIGSDLEIGQHRLKVEELRQHLWKWGFYTP DKKHQKDPPFLWMGYELHPEKWTVPPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |