Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3127 | 3127-30514 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K70T, K219D | Y188L | T39A, S68R, V106I, V118I, D123E, V179I, Q207R, H208Y, R211K, D218E, L228H |
| >3127-30514| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKNRDTWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYMDDLLVGSDLEIGQHRTKIEELRRYLWKWGFYTP EDKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73T | L10I, K20I, R41K, K55R, I62V, L63P, C67F, V77I, I93L |
| >3127-30514| codons 4-99 TLWQRPIVTIKIGGQLIEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIRVRQYDQVP IEIFGHKAITTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |