Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3183 | 3183-30515 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V, L90M | L33F, G73S | L10I, I13V, K20R, E35D, M36I, N37D, K55R, I62V, L63P, A71T, I72E, I93L, C95F |
| >3183-30515| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTVFEDIDLPGRWKPKIIGGIGGFVRVRQYDQVP IEICGHKTESTVLVGPTPANVIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | D67G, K70A, V75A, K219Q | K103KN | E40F, K43E, S68G, A98S, K102KR, V118I, K122E, S162SDGN, H208Y, R211K, D218E |
| >3183-30515| codons 38-247 CTFLEEEGKISKIGPENPYNTPVFAIKKKGGTAWRKIADFRELNKRTQDFWEVQLGIPHP SGLKRNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |