Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3088 | 3088-30501 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I50V, I54S, V82ACGS, L90LM | L10I, E34Q, Q61H, L63P, I64V, A71V, V77I, I93L |
| >3088-30501| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLQEMNLPGRWKPKIIVGVGGFSKVRQYDHIP VEICGHKVIGTVLIGPTPSNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I | K219Q | K103N, Y181YC, G190A | V108VI | T39A, S48T, K64N, K122E, I135T, E138EQ, I142IT, E203A, F214FL, H221Y |
| >3088-30501| codons 38-247 CAEMEKEGKITKIGPENPYNTPVFAINKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSTNNQTPGTRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRTKIAELRQHLLRWGLTTP DQKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |