Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3009 | 3009-30225 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | V11VI, L33F, K43T, T74TP | L10IV, I13V, N37D, K55KR, Q61QH, L63P |
| >3009-30225| codons 4-99 TLWQRPVITVKIGGQLKEALLDTGADDTVFEEMDLPGRWTPKLIGGIGGFVRVRQYDHIP IEICGHKAIGPVLVGPTPANVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K103N | V108I | S68SN, K122E, T165I, V189I, G196K, T200A, I202V, Q207E, R211K, H221Y, K238S | D113N |
| >3009-30225| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDNTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGNAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKQNPDIVIYQYVDDLYIGSDLEIKQHRAKVEELREHLWKWGFYTP DKKYQKEPPFLWMGYELHPDSWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |