Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3006 | 3006-30219 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47IV, I54L, I84V, L90M | L10F, L33F, K43T, G73AITV, T74P | I13V, L19I, K20KR, E35D, M36MI, N37E, K55R, R57K, I62V, L63P, K70R, A71AV, V77VI, I85IL |
| >3006-30219| codons 4-99 TLWQRPFVTVKIGGQIREALLDTGADDTIFEDIELPGRWTPKIVGGIGGFLRVKQYDQVP IEICGHRVIVPVLIGPTPVNVLGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210LW, T215F | K219Q | V60I, K122E, I135T, S162D, I167IV, H208Y, R211K, D218E, L228H |
| >3006-30219| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQDSMTKVLEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |