Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3059 | 3059-30414 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A | L10I, K20R, E35D, M36I, N37D, D60E, L63P, A71T, I72V, I93L |
| >3059-30414| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTILEDIDLPGRWKPKIIGGIGGFIKVRQYEQIP IEICGHKTVGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70KR, M184V, T215F | K219E | Y181C | V90I, V118I, K122E, I135R, T200TA, F214L, D218DE |
| >3059-30414| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGLFTP EEKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |