Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3056 | 3056-30403 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, L33F, Q58E, G73T | T12E, K14R, E34Q, D60DN, I62V, L63P, A71V, I72T, V77I, P79D, T91S, I93L |
| >3056-30403| codons 4-99 TLWQRPFIEIRIGGQLKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFVKVREYNQVP IEICGHKVTTTVLIGDTPVNVIGRNLMSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M, M184V | A62V, V75I, F77FL, F116Y | Y181YC, Y188L | T39A, S68G, V118I, K122E, I135T, I142V, V179I, V189VI, G196E, T200A, I202V, H208HY, F214L, D237E | T69IV, K102LM |
| >3056-30403| codons 38-247 CAEMEKEGKISKIGPENPYNTPVFVIKRKDGVKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKMKKSVTVLDVGDAYYSIPLDEDFRKYTAFTIPSTNNETPGVRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYVDDLLIGSDLEIEQHRAKVEELRQYLLRWGLTTP DKKHQKEPPFLWMGYELHPEKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |