Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3084 | 3084-30822 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74IV, M184V, T215Y | V75A, K219N | L100I, K103N | K43E, E44D, I47L, K73M, K102Q, V118I, K122KE, D123DE, S162D, D177E, G196E, T200TA, E203Q, L210S, R211K, D218E |
| >3084-30822| codons 38-247 CTELEEDGKLSKIGPENPYNTPVFAIKKKNSTKWRMVADFRELNKRTQDFWEVQLGIPHP AGIKQNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIEQHRAKIQELRQHLSKWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48A, I54V, V82S | L24I, K43T | L10I, K20R, E35D, M36I, R57K, I62V, L63P, I64V, A71V, T74S, V77I, I93L |
| >3084-30822| codons 4-99 TLWQRPIVTIKIGGQLREALIDTGADDTVLEDINLPGRWTPKMIAGIGGFVKVKQYDQVP VEICGHKVIGSVLIGPTPSNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |