Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1618 | 1618-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, T215Y | K219R | K103N | V108VI | V60I, D123E, S162C, I178L, E203D, H221Y, V245E |
| >1618-30821| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDLVIYQYMDDLYVGSDLEIGQHRTKIDELRQHLLRWGFYTP DRKYQKEPPFLWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V | L10F, L33LI, Q58E, N88D, L89V | I13V, A22V, M36I, R41K, R57RK, L63P, A71T, T74K, N83S, T91A |
| >1618-30821| codons 4-99 TLWQRPFVTVKIGGQLKEVLLDTGADDTVIEEINLPGKWKPKIIGGIGGFVKVKEYDQIP IEICGHKTIGKVLVGPTPVSVIGRDVLAQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |