Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1299 | 1299-30714 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L74I, V75T, M184V, L210W, T215Y | K219D | Y181C, G190A | K101H, V108I | K49KR, K122E, I142IT, S162A, Q174QK, E203K, R211K, D218E, D237E |
| >1299-30714| codons 38-247 CTEMEKEGKISRIGPENPYNTPVFAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSP AIFQASMTKILEPFRKKNPDIVICQYVDDLYVASDLEIGQHRTKIKELRQHLWKWGFYTP EDKHQKEPPFLWMGYELHPEKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, V82A, L90M | K43T, F53L | L10IV, I13IV, K20R, E35D, M36I, N37DE, I62V, L63P, I66F, A71I, I72V |
| >1299-30714| codons 4-99 TLWQRPVVTVKIGGQLREALLDTGADDTILEDIELPGRWTPKIVGGIGGLLKVRQYDQVP IEFCGHKIVGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |