Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1266 | 1266-30310 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, L210W, T215Y | K219R | Y188L | T39A, K43E, E44A, V60I, V106VI, V118I, K122E, S134SG, I142V, V189VI, T200A, E203D, H208Y, R211K, K223Q, L228R, Q242H, V245T |
| >1266-30310| codons 38-247 CAELEEAGKISKIGPENPYNTPIFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPGINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLLIGSDLEIGQHRAKIDELRQYLWKWGFYTP DRKHQQEPPFRWMGYELHPDKWTVHPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F | I13V, E35D, M36I, K55R, R57K, D60E, I62V, L63P, I66V, A71T, I72T, V77I, I93L, C95F |
| >1266-30310| codons 4-99 TLWQRPFVTVKIGGQLKEALLDTGADDTVFEDINLPGRWKPKIIGGIGGFVRVKQYEQVP IEVCGHKTTGTVLIGPTPVNVIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |