<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1266 1266-30310 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, L33F I13V, E35D, M36I, K55R, R57K, D60E, I62V, L63P, I66V, A71T, I72T, V77I, I93L, C95F  
>1266-30310| codons 4-99
TLWQRPFVTVKIGGQLKEALLDTGADDTVFEDINLPGRWKPKIIGGIGGFVRVKQYEQVP
IEVCGHKTTGTVLIGPTPVNVIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184V, L210W, T215Y K219R Y188L   T39A, K43E, E44A, V60I, V106VI, V118I, K122E, S134SG, I142V, V189VI, T200A, E203D, H208Y, R211K, K223Q, L228R, Q242H, V245T  
>1266-30310| codons 38-247
CAELEEAGKISKIGPENPYNTPIFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPGINNETPGVRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVIYQYVDDLLIGSDLEIGQHRAKIDELRQYLWKWGFYTP
DRKHQQEPPFRWMGYELHPDKWTVHPITLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006