Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1261 | 1261-30417 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 4 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74LI, L210W, T215Y | V75S, K219N | K103KN, Y181C | T39A, E44D, V118I, D123E, S162SACG, D177E, H208Y, R211K, D218E |
| >1261-30417| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSDKWRKISDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQGSMTKILEPFRKQNPEIVICQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82C, I84V, L90M | L10F, L33F, F53L, T74P | I13V, K55R, D60E, I62V, L63P, I66F, A71V, I72V, T91S |
| >1261-30417| codons 4-99 TLWQRPFVTVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGLVRVRQYEQVP IEFCGHKVVGPVLVGPTPCNVIGRNLMSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |