Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1255 | 1255-30409 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q151M | A62V, V75I, F116Y | K103N | P225H | S68N, A98S, D123E, D177E, T200A, R211K, F214M |
| >1255-30409| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDNTKWRKLIDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTVLDVGDAYYSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGMTTP DKKHQKEHPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V | V11VI | L10I, I13V, K20RT, A22V, E35G, M36I, N37S, R41K, R57K, D60DE, Q61QH, I62IV, L63P, K70R, A71V, I93L |
| >1255-30409| codons 4-99 TLWQRPIITVKIGGQLTEVLLDTGADDTVLEGISLPGKWKPKMIGGIGGFVKVKQYEHVP IEICGHRVIGTVLVGPTPVNVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |