Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1254 | 1254-30319 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, V82A, I84V, L90M | L10F, L33F, Q58E, G73S | I13V, L19V, E34Q, D60E, I62V, L63P, A71V |
| >1254-30319| codons 4-99 TLWQRPFVTVKIGGQVKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFLKVREYEQVP IEICGHKVISTVLVGPTPANVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, Y115F, Q151M, M184MV, T215F | F116Y, K219Q | K103N | V60I, K64H, T69N, A158S, S162Y, Q197H, I202V, H208Y, R211K, D218E, L228H, V245VE |
| >1254-30319| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIHKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAFYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP SIFQYSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGHHRTKVEELRQYLLKWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |