Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1249 | 1249-30304 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SS, T215Y | A98G | T39A, V118VI, I142V, S162CY, T200A, E203ED, R211K, L228H, Q242H, V245M |
| >1249-30304| codons 38-246 CAELEKEGKISKIGPENPYNTPVFAIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRAKIDELRQHLLKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVHPIML |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, L90M | L10F, L33F, K43T | I13V, L24F, K55R, I62V, L63P, A71V, V77I, L89I, I93L |
| >1249-30304| codons 4-99 TLWQRPFVTVKIGGQLKEALFDTGADDTVFEEMNLPGRWTPKLIGGIGGFLRVRQYDQVP IEICGHKVIGTVLIGPTPANIIGRNIMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |