Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1247 | 1247-30214 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, L90M | L10F, V11I, L33F | I13V, K55R, I62V, L63P, I66V, A71V, I93L, C95F |
| >1247-30214| codons 4-99 TLWQRPFITVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFLRVRQYDQVP IEVCGHKVIGTVLVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, V75M, M184V, L210W, T215Y | K103N | A98AG, V108VI | T39A, K43E, E44D, V118I, K122E, I135T, T165L, R211K, L228I |
| >1247-30214| codons 38-247 CAELEEDGKISKIGPENPYNTPVFAIKKKDSTKWRKVMDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMLKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFIWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |