Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1785 | 1785-30502 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, I84V, L90M | L10F, G73S, L89V | I13V, Q18H, K20T, L33V, E35EDG, M36MI, N37NK, R57K, I62V, L63PS, A71V, I72L |
| >1785-30502| codons 4-99 TLWQRPFVTVKIGGHLTEALLDTGADDTVVEGIKLPGRWKPKIIGGIGGFMKVKQYDQVS IEICGHKVLSTVVVGPTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K219N | L100I, K103N | K43E, K64KR, V118I, K122E, K166R, V179I, I202V, E203K, H208Y, R211K, K223E, L228R |
| >1785-30502| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIRKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIIIYQYVDDLYVGSDLEIGQHRTKVKELRQYLWKWGFYTP DNKHQEEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |