Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1243 | 1243-30312 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, V82T, L90M | V11I | L10I, T12IV, I15V, G16E, L19P, K20I, M36I, N37S, R41K_K, K55R, R57K, I62V, L63R, K70I, A71V, I85V, L89I |
| >1243-30312| codons 4-99 TLWQRPIIVIKVEGQPIEALLDTGADDTVLEEISLPGKWKPKIIGGIGGFMRVKQYDQVR IEICGHIVIGTVVVGPTPTNIVGRNIMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K219R | V108VI | K43Q, E44D, T69TN, T107TS, L109I, V118I, K122E, I135T, I142V, T165I, G196E, I202V, D218E, L228K |
| >1243-30312| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVSIIDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKVEELRQHLWRWGFYTP ERKHQKEPPFKWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |