Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1767 | 1767-30522 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | K70Q | Y188L | T39A, E40F, K43Q, V118I, K122E, R172K, I178M, V179VI, V189I, G196E, T200TA, E203D, E204Q, H208Y, R211K, H221Y |
| >1767-30522| codons 38-247 CAFLEQEGKISKIGPENPYNTPVFAIKKKNSDQWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFKKQNPDMIIYQYMDDLLIGSDLEIEQHRAKIDQLRQYLWKWGFYTP DKKYQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82F, I84V, L90M | V11I, Q58E, G73C | L10I, I15V, K20I, E35D, M36I, F53Y, I62V, L63P, H69Q, A71I, I72L, Q92QK, I93M |
| >1767-30522| codons 4-99 TLWQRPIITIKVGGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGYIKVREYDQVP IEICGQKILCTVLVGPTPFNVIGRNLMTKMGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |