Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1765 | 1765-30516 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75VM, M184V, L210W, T215Y | K103NS, Y181C, G190A | T39R, K43E, E44D, K49KR, V118I, K122E, T200A, E203K, Q207D, H208Y, R211K, H221Y, L228LHQ |
| >1765-30516| codons 38-247 CRELEEDGKISRIGPENPYNTPVFAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKSKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRAKIKELRDYLWKWGFYTP DKKYQKEPPFQWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82T, L90M | L33F, F53L, G73S | L10I, I15V, K20R, E35D, M36L, N37E, K55R, I62V, L63P, A71V, V77I, I85V, F99Y |
| >1765-30516| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTIFEDLELPGRWKPKIVGGIGGLVRVRQYDQVP IEICGHKVISTVLIGPTPTNIVGRNLMTQIGCTLNY |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |