Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1986 | 1986-30724 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, T215Y | K103N, Y181C | K43E, E44D, T69TA, D123E, T200A, Q207A, H208Y, R211K, W212C, H221C, V245L | I180M |
| >1986-30724| codons 38-247 CTELEEDGKISKIGPENPYNTPVFAIKKKNSAKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVMCQYMDDLYVGSDLEIGQHRAKIEELRAYLLKCGFYTP DKKCQKEPPFLWMGYELHPDKWTVQPILLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I50V, I54T, V82A | L10I, I15V, L19I, K20R, E34K, E35D, M36I, R41K, I64V, T74S |
| >1986-30724| codons 4-99 TLWQRPIVTIKVGGQIREALLDTGADDTVLKDINLPGKWKPKIIVGVGGFTKVRQYDQIL VEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |