Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1203 | 1203-30325 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K219R | K103N, Y181C | K43E, K101KQ, V118VI, K122E, I135L, I178IV, E203EK, R211RK, D218DE, K223KQ, L228R |
| >1203-30325| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDVVICQYMDDLYVGSDLEIGQHRTKIKELRQHLWKWGFYTP ERKHQQEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A | L33F | L10V, I13V, N37HY, R41I, I62V, L63T, T74A, I85V, L89M, T91A |
| >1203-30325| codons 4-99 TLWQRPVVTVKIGGQLKEALLDTGADDTVFEEMYLPGIWKPKLIVGIGGFVKVRQYDQVT IEICGHKAIGAVLVGPTPANIVGRNMLAQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |