Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1191 | 1191-30228 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, I84V, L90M | L10F, G73A | K20I, E35D, R41K, K55R, R57K, I62V, L63P, H69C, A71T, I72T, Q92QK, I93L |
| >1191-30228| codons 4-99 TLWQRPFVTIKIGGQLIEALLDTGADDTVLEDMNLPGKWKPKIIGGIGGFVRVKQYDQVP IEICGCKTTATVLVGPTPVNVIGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | K103N | K122E, D123DGNS, Q174K, D177E, Q207E, R211K, V245E |
| >1191-30228| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPEIVIYQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |