Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1176 | 1176-30519 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | K219KR | K103N, Y181C | K43KQ, K49R, A98S, V111I, V118I, K122E, I142V, S162D, S163CR, V179VI, I195K, G196E, T200A, H221Y | D186DH |
| >1176-30519| codons 38-247 CTELEQEGKISRIGPENPYNTPVFAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTVLDIGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQDRMTKILEPFRKQNPDIIICQYVDHLYVGSDLEKEQHRAKIEELRQHLWRWGFYTP DRKYQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | L10F, V11I | I13V, K20I, E34Q, M36I, G51A, R57RK, I62V, L63P, H69Q, A71V, G73D, P79S, Q92K |
| >1176-30519| codons 4-99 TLWQRPFITVKIGGQLIEALLDTGADDTVLQEINLPGRWKPKIIGGIAGFMKVKQYDQVP IEICGQKVIDTVLVGSTPVNVIGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |