Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1159 | 1159-31223 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 34 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54T, V82T, I84V | L33LF | L10I, T12I, L19V, D60E, Q61G, L63P, A71V, V77I, I93L |
| >1159-31223| codons 1-99 PQITLWQRPIVIIKIGGQVKEALLDTGADDTVFEEMNLPGRWKPKIIVGIGGFTKVRQYE GIPIEICGHKVIGTVLIGPTPTNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, M184V, L210W, T215Y | K103N | V35T, K43N, V118VI, K122E, D123E, D177N, R206RK, Q207E, A272P, K277R, K281R, T286A, E297K, G333GE, A371V, A376S |
| >1159-31223| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELENEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYVDDLYVGSDLEIGQHRTKIEELKEHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEVVQKISTESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |