Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2323 | 2323-30724 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69G_SG, M184I, T215Y | A62V | K101E, Y181C | A98G | V118I, K122E, I135V, K166KR, T200A, E204EG, L228LR |
| >2323-30724| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDSGKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIVICQYIDDLYVGSDLEIGQHRAKIEGLRQHLLRWGFYTP DKKHQKEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | V11VI, L33F, Q58E | L10I, M36L, K55R, I62V, L63P, I66F, C67G, A71T, I72K, V77I, I93L, C95F |
| >2323-30724| codons 4-99 TLWQRPIITIKIGGQLKEALLDTGADDTVFEELNLPGRWKPKIIGGIGGFVRVREYDQVP IEFGGHKTKGTVLIGPTPANIIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |