Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1947 | 1947-30527 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219E | K101EQ, Y181C, G190S | T39TA, S68G, T69N, K122E, I135IV, I142V, R211K, L228H |
| >1947-30527| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKNGNKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVSSDLEIGQHRTKIEELRQHLWKWGFYTP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L33F, G73T | L10I, R41RK, L63P, H69HR, K70KR, A71I, I93M |
| >1947-30527| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTIFEEMNLPGKWKPKIVGGIGGFLKVRQYDQIP IEICGRRIITTVLVGPTPVNVIGRNLMTQMGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |