Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2299 | 2299-30818 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | K103N, Y181C, G190A | A98AG | K43Q, V60I, V118I, K122E, T200A, H208Y, R211K |
| >2299-30818| codons 38-247 CTELEQEGKISKIGPENPYNTPIFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRAKIEELRQYLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, L90M | L10F, V11I, L33F, G73S, N83D | T12S, I13V, L19I, E34V, M36L, N37ND, I62V, L63P, A71V |
| >2299-30818| codons 4-99 TLWQRPFISVKIGGQIKEALLDTGADDTIFVELDLPGRWKPKIIGGIGGFIKVRQYDQVP IEICGHKVISTVLVGPTPVDIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |