Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2236 | 2236-30725 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V | Q58E, L89V | L10I, I13V, K20V, P39S, R41K, K55R, L63P, H69Q, A71T, Q92K |
| >2236-30725| codons 4-99 TLWQRPIVTVKIGGQLVEALLDTGADDTVLEEMNLSGKWKPKIIGGIGGFVRVREYDQIP IEICGQKTIGTVLVGPTPVNVIGRNVLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | A62V | Y181C, G190A | K101H | T39A, D177E, Q207E, H208Y, R211K, L228R, V241I |
| >2236-30725| codons 38-247 CAELEKEGKISKIGPENPYNTPVFVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYMDDLYVASDLEIGQHRTKIEELREYLLKWGFYTP DKKHQKEPPFRWMGYELHPDKWTIQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |