<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1495 1495-30527 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82C, I84V L24I, V32V_F, T74P L10I, I13V, K14KR, L19LI, M36L, R41K, K55R, I62V, L63P, L89M  
>1495-30527| codons 4-99
TLWQRPIVTVRIGGQIKEALIDTGADDTVLEELNLPGKWKPKLIGGIGGFVRVRQYDQVP
IEICGHKAIGPVLVGPTPCNVIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y   Y181C, G190A A98G, K101H, V108I T39K, K43E, E44ED, K64KR, R83K, K103KR, V118I, D123E, I135V, S162CY, V189VI, R211RK, D218E, K223KQ, L228R, I244IV  
>1495-30527| codons 38-247
CKELEEDGKISKIGPENPYNTPVFAIRKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHP
GGLHKRKSVTILDVGDAYFSIPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQYSMTKILEPFRKQNPDIVICQYMDDLYIASDLEIGQHRTKIEELRQHLWKWGFYTP
EKKHQQEPPFRWMGYELHPDKWTVQPVVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006