Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1495 | 1495-30527 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82C, I84V | L24I, V32V_F, T74P | L10I, I13V, K14KR, L19LI, M36L, R41K, K55R, I62V, L63P, L89M |
| >1495-30527| codons 4-99 TLWQRPIVTVRIGGQIKEALIDTGADDTVLEELNLPGKWKPKLIGGIGGFVRVRQYDQVP IEICGHKAIGPVLVGPTPCNVIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | Y181C, G190A | A98G, K101H, V108I | T39K, K43E, E44ED, K64KR, R83K, K103KR, V118I, D123E, I135V, S162CY, V189VI, R211RK, D218E, K223KQ, L228R, I244IV |
| >1495-30527| codons 38-247 CKELEEDGKISKIGPENPYNTPVFAIRKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHP GGLHKRKSVTILDVGDAYFSIPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVICQYMDDLYIASDLEIGQHRTKIEELRQHLWKWGFYTP EKKHQQEPPFRWMGYELHPDKWTVQPVVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |