Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1763 | 1763-30424 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V | T4S, L10V, T12M, I15V, L19V, K20R, M36I, L63T, A71V, I72T, T74E, I93L |
| >1763-30424| codons 4-99 SLWQRPVVMIKVGGQVREALLDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYDQIT IEICGHKVTGEVLVGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | V75T, K219D | K103N, Y181C, G190A | A98G | T39A, K101Q, V118VI, K122E, I135L, T200A, E203K, Q207QE, K223Q, L228H |
| >1763-30424| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHP GGLQKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRAKIKELREHLWRWGFYTP DDKHQQEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |