Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1489 | 1489-30320 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82T, L90M | L10R, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I72V, I93L |
| >1489-30320| codons 4-99 TLWQRPRVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKIVGGIGGFVKVRQYDQVP IEICGHKVVGTVLVGPTPTNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | K70KN | V106VA | F227L | E40F, K43KE, V60I, R83K, S105ST, K122E, I135V, I178L, V179I, T200A, Q207K, H208Y, R211E, K223E, L228R |
| >1489-30320| codons 38-247 CTFLEEEGKISKIGPENPYNTPIFAIKKKDSTNWRKLMDFRELNKKTQDFWEVQLGIPHP AGLKKKKTATVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDLIIYQYVDDLYVGSDLEIGQHRAKIEELRKYLWEWGFYTP DKKHQEEPPLRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |