<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1487 1487-30320 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75M, K219R V106A, G190A F227L T39E, E44D, V60I, S105T, V118I, D121H, K122E, A158S, S162C, E169D, D177E, V179I, G196E, T200A, E203D, H208Y, R211K, H221Y, K223Q  
>1487-30320| codons 38-247
CEELEKDGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP
AGLKKKKTATVLDVGDAYFSIPLHEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
SIFQCSMTKILDPFRKQNPEIIIYQYMDDLYVASDLEIEQHRAKIDELRQYLWKWGFYTP
DRKYQQEPPLLWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54L, I84V, L90M V11IL, L33F, F53FL, L89V L10IV, K14KR, G16A, L19I, L63P, I64L, A71I, V77VI, I93L  
>1487-30320| codons 4-99
TLWQRPVLTIRIAGQIKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGLLKVRQYDQIP
LEICGHKIIGTVLIGPTPVNVIGRNVMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006