Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1487 | 1487-30320 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K219R | V106A, G190A | F227L | T39E, E44D, V60I, S105T, V118I, D121H, K122E, A158S, S162C, E169D, D177E, V179I, G196E, T200A, E203D, H208Y, R211K, H221Y, K223Q |
| >1487-30320| codons 38-247 CEELEKDGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKKKTATVLDVGDAYFSIPLHEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP SIFQCSMTKILDPFRKQNPEIIIYQYMDDLYVASDLEIEQHRAKIDELRQYLWKWGFYTP DRKYQQEPPLLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | V11IL, L33F, F53FL, L89V | L10IV, K14KR, G16A, L19I, L63P, I64L, A71I, V77VI, I93L |
| >1487-30320| codons 4-99 TLWQRPVLTIRIAGQIKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGLLKVRQYDQIP LEICGHKIIGTVLIGPTPVNVIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |