Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2436 | 2436-40706 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 46 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75M, M184V, L210W, T215F | K219E | G190Q | E6D, M16V, E44D, T69N, K101Q, L109I, V118I, K122E, D123N, I135T, G196E, H208Y, R211K, L228Q, D237E, A272P, V276I, L283I, I293V, P294PA, E297K, G333E, R356K, M357R, G359S, Q367L, A371V, K390R | E89D |
| >2436-40706| codons 1-399 PISPIDTVPVKLKPGVDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSNRWRKIMDFRELNKRTQDFWDVQLGIPHPAGLQKKKSVTVIDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVQSDLEIEQHRTKIEELRQYLWKWGFFTPDEKHQKEPPFQWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLIRGTKALTEVVALTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKRRSA HTNDVKLLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | V32L, G73C | I13V, K14R, K20R, E35D, M36I, N37D, K55R, R57K, Q61E, I62V, L63P, A71T, I72K, T91N, Q92K |
| >2436-40706| codons 1-99 PQITLWQRPLVTVRIGGQLREALLDTGADDTLLEDIDLPGRWKPKIIGGIGGFVRVKQYD EVPIEICGHKTKCTVLVGPTPVNVIGRNLMNKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |