<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2436 2436-31120 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 12

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, G73C I13V, K14R, K20R, E35D, M36I, N37D, K55KR, R57K, Q61E, I62V, L63P, H69Q, A71T, I72K, T91N, Q92K  
>2436-31120| codons 1-99
PQITLWQRPFVTVRIGGQLREALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVRVKQYD
EVPIEICGQKTKCTVLVGPTPVNVIGRNLMNKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, V75M, M184V, L210W, T215F K219E G190Q   E6D, M16V, E44D, T69N, K101Q, L109I, V118I, K122E, D123N, I135IT, G196E, H208Y, R211K, L228QR, D237E, A272P, V276I, L283I, I293V, E297K, G333E, R356K, M357R, G359S, Q367L, A371V, K390R  
>2436-31120| codons 1-399
PISPIDTVPVKLKPGVDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSNRWRKIMDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVIDVGDAYFSIPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVQSDLEIEQHRTKIEELRQYLWKWGFFTPDEKHQKEPPFRWMGYELHPEKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLIRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKRRSA
HTNDVKLLTEVVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006