Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1863 | 1863-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | Q58E, G73S | L10I, I13M, M36MI, L63P, I66V, H69R, I93L, C95F |
| >1863-30821| codons 4-99 TLWQRPIVTMKIGGQLKEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVREYDQIP IEVCGRKAISTVLVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215F | T39TA, D123E, I142V, K166Q, D177E, L228R, V245T |
| >1863-30821| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTQILEPFRKQNPEIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFFTP DKKHQKEPPFRWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |