Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1474 | 1474-30512 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | T39A, V60VI, A98S, V118VI, K122E, T139K, I142V, S162A, T165TI, Q207E, V245K |
| >1474-30512| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNEKPGVRYQYNVLPQGWKGSP AIFQASMIKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELREHLWRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, L90M | L33F, G73A | L10I, N37S, R41K, K55R, D60E, Q61QH, L63P, I64V, I72L, V77I, I93L |
| >1474-30512| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMSLPGKWKPKIIGGIGGFVRVRQYEHIP VEICGHKALATVLIGPTPFNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |