Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1757 | 1757-30604 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, M184V, T215F | K219Q | K103N, G190A | F227L | T39AS, E40ED, A98S, K102Q, V106VI, I135V, K166R, I167V, G196E, I202IV, E203K, Q207E, H208Y, H221Y, L228H, Q242H, V245M | D186DY |
| >1757-30604| codons 38-247 CSDLEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKQNKSITVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRVLEPFRKQNPDIVIYQYVDYLYVASDLEIEQHRTKVKELREYLLRWGFFTP DQKYQKEPPLHWMGYELHPDKWTVHPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A | L24I, F53L | L10I, N37D, K55R, L63E, I64V, E65D, T74S, V77I |
| >1757-30604| codons 4-99 TLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMDLPGRWKPKLIVGIGGLVRVRQYDQIE VDICGHKAIGSVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |