<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1757 1757-30604 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48V, I54V, V82A L24I, F53L L10I, N37D, K55R, L63E, I64V, E65D, T74S, V77I  
>1757-30604| codons 4-99
TLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMDLPGRWKPKLIVGIGGLVRVRQYDQIE
VDICGHKAIGSVLIGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, M184V, T215F K219Q K103N, G190A F227L T39AS, E40ED, A98S, K102Q, V106VI, I135V, K166R, I167V, G196E, I202IV, E203K, Q207E, H208Y, H221Y, L228H, Q242H, V245M D186DY
>1757-30604| codons 38-247
CSDLEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP
SGLKQNKSITVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTRVLEPFRKQNPDIVIYQYVDYLYVASDLEIEQHRTKVKELREYLLRWGFFTP
DQKYQKEPPLHWMGYELHPDKWTVHPIMLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006