Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1283 | 1283-30220 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | Y181C | T39A, K64KR, K122E, D123N, I135R, I202V, E224D |
| >1283-30220| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRTKVEELRQHLWRWGFYTP DKKHQKDPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54M, V82A, L90M | L10F, L33F, K43KT | T12P, I13V, K14R, K20KT, N37D, R57K, I62V, L63P, A71V, I93L, C95F |
| >1283-30220| codons 4-99 TLWQRPFVPVRIGGQLTEALLDTGADDTVFEEMDLPGRWTPKLIGGIGGFMKVKQYDQVP IEICGHKVIGTVLVGPTPANIIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |