Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1145 | 1145-30401 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 2 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K103N, Y181YC | T39A, K43E, E44D, W88WC, A98S, V118I, K122E, T200A, E203D, Q207T, H208Y, R211K, L228H |
| >1145-30401| codons 38-247 CAELEEDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFCEVQLGIPHP SGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRAKIDELRTYLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, I84V | L24I, L33F, K43T, L89V | L10I, I13V, K20R, E35D, M36I, N37E, L63P, A71V, P79S, T91S, I93L |
| >1145-30401| codons 4-99 TLWQRPIVTVKIGGQLREALIDTGADDTVFEDIELPGRWTPKLIGGIGGFLKVRQYDQIP IEICGHKVIGTVLVGSTPANVIGRNVLSQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |