Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2231 | 2231-30715 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, L74V, M184V, T215F | K219Q | K101E, Y181C, G190S | V60I, A98S, I135V, D218E, L228H, V245I |
| >2231-30715| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP SGLEKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVSSDLEIGQHRTKIEELRQHLLRWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIILP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, V82A, L90M | L10FI | T12TP, I13V, Q18H, K20I, R41K, K55R, D60E, L63P, A71I, I93L, C95F |
| >2231-30715| codons 4-99 TLWQRPIVPVKIGGHLIEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFMRVRQYEQIP IEICGHKIIGTVLVGPTPANIIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |