Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2100 | 2100-30613 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46I, I54L, V82VAIT, I84V | Q58E | L10I, T12K, I15V, G16A, L19I, K20R, M36I, N37A, G51A, L63C, I66F, A71V, T91S |
| >2100-30613| codons 4-99 TLWQRPIVKIKVAGQIREALLDTGADDTILEEIALPGRWKPKIIGGIAGFLKVREYDQIC IEFCGHKVIGTVLVGPTPTNVIGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, T215Y | D67G, K219E | E44ED, S68G, V118VI, K122E, I178M, T200A, D218E, L228LH |
| >2100-30613| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKGGTRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFYTP EEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |