Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1437 | 1437-30731 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | Q58QE, G73C | L10I, I15V, K20R, M36I, R41K, D60E, I62V, L63P, H69HR, I72L |
| >1437-30731| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTVLEEINLPGKWKPKIIGGIGGFVKVREYEQVP IEICGRKALCTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T215Y | V179VD | K103R, Q207E, R211K, P243T, V245T |
| >1437-30731| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKRKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIDIYQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQTITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |