Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2275 | 2275-30725 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75T, T215Y | K219E | K103N, Y181C | K49R, K122E, D123N, I135V, S162C, E169D, P170L, L228H |
| >2275-30725| codons 38-247 CTELEKEGKISRIGPENPYNTPVFAIKKKNSTRWRKLTDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILDLFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, N88S | L10F, L33F | I13V, L19V, K20T, R57K, L63P, A71T, V77I |
| >2275-30725| codons 4-99 TLWQRPFVTVKIGGQVTEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFIKVKQYDQIP IEICGHKTIGTVLIGPTPVNVIGRSLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |