Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2050 | 2050-30625 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | Y188L | A98G | V60I, K102KM, K122E, S162ST, D177E, I202V, Q207K, H208Y, R211S, F214L, H221Y |
| >2050-30625| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKMKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQTSMTKILEPFRKQNPEIVIYQYMDDLLVGSDLEIGQHRTKVEELRKYLLSWGLFTP DQKYQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, L90M | N88D | L10I, I15V, L19V, E35D, M36I, N37S, L63P, I85V, Q92K |
| >2050-30625| codons 4-99 TLWQRPIVTIKVGGQVKEALLDTGADDTILEDISLPGRWKPKIVGGIGGFIKVRQYDQIP IEICGHKAIGTVLVGPTPVNIVGRDLMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |