Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2160 | 2160-30702 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, V11I, G73S | I15V, K20T, E34T, E35D, N37T, I62V, L63P, A71V, I85V |
| >2160-30702| codons 4-99 TLWQRPFITIKVGGQLTEALLDTGADDTVLTDMTLPGRWKPKMIGGIGGFVKVRQYDQVP IEICGHKVISTVLVGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | Y181C | A98AG | E44D, K82R, K122E, I135V, T139V, S162C, E203K, H208Y, R211K, K223Q |
| >2160-30702| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNRRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNEVPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIKELRQYLWKWGFYTP DNKHQQEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |